The FXB Center for Health and Human Rights advances the rights and wellbeing of children, adolescents, youth, and their families living in the most extreme circumstances worldwide. We conduct innovative field research that takes a rights-based approach in order to understand the constraints and obstacles faced by these marginalized populations and to discern possibilities for release and empowerment. We deploy a range of methods derived from public health and law, social science and humanities. We work with local partners and with the children, adolescents, youth and families in the design and piloting of positive interventions. We strive to find sustainable solutions that can be scaled up. We translate our findings into policy recommendations and practice at all relevant levels of government and civil society.